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In collaborazione con le principali aziende farmaceutiche e biotecnologiche, Renishaw sta sviluppando dispositivi impiantabili per il rilascio di terapie per il trattamento delle malattie gravi del sistema nervoso centrale.

Più precisione nel rilascio di terapie

Immagine neurologica

Renishaw sta collaborando con le aziende biotecnologiche e farmaceutiche leader per garantire che i prodotti terapeutici che si dimostrano promettenti in laboratorio abbiano una modalità di rilascio affidabile durante le prove cliniche.

In passato, la complessità di questo passaggio ha provocato il mancato raggiungimento degli obiettivi in programmi terapeutici di grande potenziale.

In molti casi importanti il fallimento può essere attribuito, almeno in parte, alla mancata capacità di eseguire in maniera sistematica un rilascio preciso unito ad un contenimento del farmaco nei volumi prestabiliti.

Ulteriori informazioni

Renishaw sta sviluppando una gamma di dispositivi di inserimento di prossima generazione che dimostrano una ripetibilità negli schemi di infusione e permettono un'efficacia costante nelle terapie osservate.

Oltre a permettere di incorporare questa gamma di sviluppi nei programmi terapeutici e di ricerca accademica, Renishaw offre un servizio di consulenza e di collaborazione nello sviluppo per permettere alle aziende biotecnologiche e farmaceutiche di sviluppare sistemi di rilascio precisi, al fine di ottenere un rilascio ottimale dei loro prodotti terapeutici.

Biblioteca articoli peer reviewed

I prodotti neurologici Renishaw appaiono in numerose pubblicazioni peer reviewed, compresi gli articoli descritti di seguito. Questi articoli confermano l'utilizzo efficace dei nostri prodotti nel campo della neurochirurgia funzionale.

Prodotto

Applicazione

Autori

Anno

Titolo

Link DOI

Modulo di registrazione senza casco neurolocate™SEEGCardinale F. et al 2017A new tool for touch-free patient registration for robotic-assisted intercranial surgery: application accuracy from a phantom study and a retrospective surgical seriesDOI
Software neuroinspire™DBSGeevarghese, R. et al2016Registration accuracy of CT/MRI fusion for localisation of deep brain stimulation electrode position: an imaging study and systematic reviewDOI
Somministrazione del farmacoSomministrazione del farmacoBarua, N.U. et al2016A novel implantable catheter system with transcutaneous port for intermittent convection-enhanced delivery of carboplatin for recurrent glioblastomaDOI
neuromate ® stereotactic robotDBSKajita, Y. et al2015Installation of a neuromate robot for stereotactic surgery: efforts to conform to Japanese specifications and an approach for clinical useDOI
neuromate ® stereotactic robotDBS von Langsdorf, D. et al  2015In vivo measurement of the frame-based application accuracy of the neuromate neurosurgical robotDOI
neuromate ® stereotactic robot Porfirio, B. et al 2015 Donor-specific anti-HLA antibodies in Huntington's disease recipients of human fetal striatal graftsDOI
neuromate ® stereotactic robotSEEG Cardinale, F. 2015 Stereotactic robotic application accuracy is very high in 'in vivo' proceduresDOI
neuromate ® stereotactic robotCell graftPaganini, M. et al 2013 Fetal striatal grafting slows motor and cognitive decline of Huntington's disease DOI
neuromate ® stereotactic robotSEEGAbhinav, K. et al2013Use of robot-guided stereotactic placement of intracerebral electrodes for investigation of focal epilepsy: initial experience in the UKDOI

neuromate ® stereotactic robot

Somministrazione del farmaco

Barua, N.U. et al

2013

Robot-guided convection-enhanced delivery of carboplatin for advanced brainstem glioma. Acta Neurochirurgica

DOI

neuromate ® stereotactic robotSEEGCardinale F. et al2013Stereoelectroencephalography: Surgical Methodology, Safety, and Stereotactic Application Accuracy in 500 Procedures. Neurosurgery, 72(3):353-366DOI
neuromate ® stereotactic robotSEEGSieradzan, K. et al2013Robotic stereo EEG in epilepsy surgery assessment, Journal of Neurology, Neurosurgery and Psychiatry, 84(e2):46DOI
neuromate ® stereotactic robotBiopsiaDellaretti, M. et al2012Stereotactic Biopsy for Brainstem Tumors: Comparison of Transcerebellar with Transfrontal Approach, Stereotactic and Functional Neurosurgery, 90:79-83DOI
neuromate ® stereotactic robotBiopsiaDellaretti, M. et al2012Correlation between magnetic resonance imaging findings and histological diagnosis of intrinsic brainstem lesions in adults, Neuro-Oncology, 14(3):381-385DOI
neuromate ® stereotactic robotSEEGCossu, M. et al2012Stereoelectroencephalography in the presurgical evaluation of focal epilepsy in infancy and early childhood. Journal of Neurosurgery: Pediatrics, 9(3):290-300DOI
neuroguide ® - DBS electrode delivery systemDBSKhan, S. et al2010A magnetic resonance imaging-directed method for transventricular targeting of midline structures for deep brain stimulation using implantable guide tubes. Neurosurgery, 66(6 Suppl Operative):234-7DOI
neuromate ® stereotactic robotBiopsiaHaegelen, C. et al2010Stereotactic robot-guided biopsies of brain stem lesions: Experience with 15 cases.DOI
neuromate ® stereotactic robotCell graftGallina, P. et al2010Human striatal neuroblasts develop and build a striatal-like structure into the brain of Huntington's disease patients after transplantation. Experimental neurology, 222(1):30-41DOI
neuromate ® stereotactic robotSEEGAfif, A. et al2010Anatomofunctional organization of the insular cortex: A study using intracerebral electrical stimulation in epileptic patients. Epilepsia, 51(11):2305-15DOI
neuromate ® stereotactic robotSEEGAfif, A. et al2010Middle short gyrus of the insula implicated in speech production: Intracerebral electric stimulation of patients with epilepsy. Epilepsia, 51(2):206-13DOI
neuroguide ® - DBS electrode delivery systemDBSKhan, S. et al2009High frequency stimulation of the mamillothalamic tract for the treatment of resistant seizures associated with hypothalamic hamartoma. Epilepsia, 50(6):1608-11DOI
neuromate ® stereotactic robotTranscranial magnetic stimulationNarayana, S. et al2009A noninvasive imaging approach to understanding speech changes following deep brain stimulation in Parkinson's disease. American journal of speech-language pathology, 18(2):146-61DOI
neuromate ® stereotactic robotCell graftGallina, P. et al2008Development of human striatal anlagen after transplantation in a patient with Huntington's disease. Experimental neurology, 213(1):241-4DOI
neuromate ® stereotactic robotCell graftGallina, P. et al2008Human fetal striatal transplantation in Huntington's disease: a refinement of the stereotactic procedure. Stereotactic and functional neurosurgery, 86(5):308-13DOI
neuromate ® stereotactic robotCell graftPaganini, M. et al2008Fetal striatal grafting slows motor and cognitive decline of Huntington's disease. Journal of Neurology, Neurosurgery and PsychiatryDOI
neuromate ® stereotactic robotCell graftDerrey, S. et al2008Management of cystic craniopharyngiomas with stereotactic endocavitary irradiation. Neurosurgery, 63(6):1045-52DOI
neuromate ® stereotactic robotDBSBreit, S. et al2008Pretargeting for the implantation of stimulation electrodes into the subthalamic nucleus: a comparative study of magnetic resonance imaging and ventriculography. Neurosurgery, 62(2 Suppl):840-52DOI
neuromate ® stereotactic robotEndoscopyDorfmüller, G. et al2008[Surgical disconnection of hypothalamic hamartomas]. Neuro- Chirurgie, 54(3):315-9DOI
neuromate ® stereotactic robotGeneraleXia, T. et al2008An integrated system for planning, navigation and robotic assistance for skull base surgery. The international journal of medical robotics + computer assisted surgery, 4(4):321-3 0DOI
neuromate ® stereotactic robotSEEGAfif, A. et al2008Safety and usefulness of insular depth electrodes implanted via an oblique approach in patients with epilepsy.
Neurosurgery, 62(5 Suppl 2):ONS471-9
DOI
neuromate ® stereotactic robotSEEGAfif, A. et al2008Middle short gyrus of the insula implicated in pain processing.
Pain, 138(3):546-55
DOI
neuromate ® stereotactic robotSEEGCossu, M. et al2008[Presurgical evaluation of intractable epilepsy using stereo- electro-encephalography methodology: principles, technique and morbidity]. Neuro-Chirurgie, 54(3):367-73DOI
neuromate ® stereotactic robotSEEGBulteau, C. et al2008[Epilepsy surgery during infancy and early childhood in France]. Neuro-Chirurgie, 54(3):342-6DOI
neuromate ® stereotactic robotSEEGCossu, M. et al2008Epilepsy surgery in children: results and predictors of outcome on seizures. Epilepsia, 49(1):65-72DOI
neuromate ® stereotactic robotTranscranial magnetic stimulationLaird, A. et al2008Modeling motor connectivity using TMS/PET and structural equation modeling. NeuroImage, 41(2):424-36DOI
neuroguide ® - DBS electrode delivery systemDBSPatel, N.K. et al2007Magnetic resonance imaging-directed method for functional neurosurgery using implantable guide tubes. Neurosurgery, 61(5 Suppl 2):358-65DOI
neuromate ® stereotactic robotEndoscopyProcaccini, E. et al2006Surgical management of hypothalamic hamartomas with epilepsy: the stereoendoscopic approach. Neurosurgery, 59(4 Suppl 2):
ONS336-44
DOI
neuromate ® stereotactic robotGeneraleVarma, T. et al2006Use of the NeuroMate stereotactic robot in a frameless mode for functional neurosurgery. The international journal of medical robotics + computer assisted surgery,2(2):107-13DOI
neuromate ® stereotactic robotSEEGCossu, M. et al2006Stereo-EEG in children. Child's nervous system, 22(8):766- 78DOI
neuromate ® stereotactic robotTranscranial magnetic stimulationFox, P. et al2006Intensity modulation of TMS-induced cortical excitation: primary motor cortex. Human brain mapping, 27(6):478-87DOI
neuromate ® stereotactic robotDBSHaegelen, C. et al2005Does subthalamic nucleus stimulation affect the frontal limbic areas? A single-photon emission computed tomography study using a manual anatomical segmentation method.
Surgical and radiologic anatomy, 27(5):389-94
DOI
neuromate ® stereotactic robotDBSSauleau, P. et al2005Motor and non motor effects during intraoperative subthalamic stimulation for Parkinson's disease. Journal of neurology, 252(4):457-64DOI
neuromate ® stereotactic robotGeneraleRossi, A. et al2005A telerobotic haptic system for minimally invasive stereotactic neurosurgery. The international journal of medical robotics + computer assisted surgery, 1(2):64-75DOI
neuromate ® stereotactic robotSEEGCossu, M. et al2005Stereoelectroencephalography in the presurgical evaluation of children with drug-resistant focal epilepsy. Journal of neurosurgery, 103(4 Suppl):
333-43
DOI
neuromate ® stereotactic robotSEEGCossu, M. et al2005Stereoelectroencephalography in the presurgical evaluation of focal epilepsy: a retrospective analysis of 215 procedures. Neurosurgery, 57(4):706-18DOI
neuromate ® stereotactic robotGeneraleZamorano, L. et al2004Robotics in neurosurgery: state of the art and future technological challenges. The international journal of medical robotics + computer assisted surgery, 1(1):7-22DOI
neuromate ® stereotactic robotTranscranial magnetic stimulationFox, P. et al2004Column-based model of electric field excitation of cerebral cortex. Human brain mapping, 22(1):1-14DOI
neuromate ® stereotactic robotTranscranial magnetic stimulationLancaster, J. L. et al2004Evaluation of an image-guided, robotically positioned transcranial magnetic stimulation system. Human brain mapping, 22(4):329-40DOI
neuromate ® stereotactic robotDBSVarma, T. et al2003Use of the NeuroMate stereotactic robot in a frameless mode for movement disorder surgery. Stereotactic and functional neurosurgery, 80(1-4):132-5DOI
neuromate ® stereotactic robotDBSLittlechild, P. et al2003Variability in position of the subthalamic nucleus targeted by magnetic resonance imaging and microelectrode recordings as compared to atlas co-ordinates. Stereotactic and functional neurosurgery, 80(1-4):82-7DOI
neuromate ® stereotactic robotTranscranial magnetic stimulationLee, J. S. et al2003Positron emission tomography during transcranial magnetic stimulation does not require μ-metal shielding, NeuroImage, 19(4):1812-9DOI
neuromate ® stereotactic robotGeneraleLi, Q. et al2002The application accuracy of the NeuroMate robot ⬜ A quantitative comparison with frameless and frame-based surgical localization systems. Computer aided surgery, 7(2):90-8DOI